Serpens (Ancient Greek: Ὄφις, romanized: Óphis, lit. 'the Serpent') is a constellation in the northern celestial hemisphere. One of the 48 constellations listed by the 2nd-century astronomer Ptolemy, it remains one of the 88 modern constellations designated by the International Astronomical Union. It is unique among the modern constellations in being split into two non-contiguous parts, Serpens Caput (Serpent Head) to the west and Serpens Cauda (Serpent Tail) to the east. Between these two halves lies the constellation of Ophiuchus, the "Serpent-Bearer". In figurative representations, the body of the serpent is represented as passing behind Ophiuchus between Mu Serpentis in Serpens Caput and Nu Serpentis in Serpens Cauda.

The brightest star in Serpens is the red giant star Alpha Serpentis, or Unukalhai, in Serpens Caput, with an apparent magnitude of 2.63. Also located in Serpens Caput are the naked-eye globular cluster Messier 5 and the naked-eye variables R Serpentis and Tau⁴ Serpentis. Notable extragalactic objects include Seyfert's Sextet, one of the densest galaxy clusters known; Arp 220, the prototypical ultraluminous infrared galaxy; and Hoag's Object, the most famous of the very rare class of galaxies known as ring galaxies.

Part of the Milky Way's galactic plane passes through Serpens Cauda, which is therefore rich in galactic deep-sky objects, such as the Eagle Nebula (IC 4703) and its associated star cluster Messier 16. The nebula measures 70 light-years by 50 light-years and contains the Pillars of Creation, three dust clouds that became famous for the image taken by the Hubble Space Telescope. Other striking objects include the Red Square Nebula, one of the few objects in astronomy to take on a square shape; and Westerhout 40, a massive nearby star-forming region consisting of a molecular cloud and an H II region.